How Obesity Increases the Risk of Developing Type 2 Diabetes and Some Cancers

Aditta Das; Faroque Md Mohsin; Banasree Roy Urmi; Sinigdha Islam; Mahmudul Hasan; Shekh Mohammad Mostafa; Md. Jobaer Rahman Rashed; MD Mehedi Hasan; Zahidul Mostafa; Rajib Kumar Malakar; Maherun Nesa

Aditta Das Hebei Medical University, Shijiazhuang, CN, MBBS, China
Faroque Md Mohsin MPH, MSS, MBBS, Medical Officer, Directorate General of Health Services, Bangladesh https://orcid.org/0000-0003-3432-4559
Banasree Roy Urmi Medical Officer, American Hospital, Dubai, UAE https://orcid.org/0009-0008-0933-5495
Sinigdha Islam MBBS, MPH, ZWH Medical Care PC NY, USA https://orcid.org/0009-0002-0055-9739
Mahmudul Hasan Medical Officer & Incharge, Dept. of Medicine, Social Islami Bank Foundation Hospital, Dhaka, Bangladesh
Shekh Mohammad Mostafa UHFPO, Directorate General of Health Services, Bangladesh https://orcid.org/0000-0002-9089-3150
Md. Jobaer Rahman Rashed MPP Student, Humphrey School of Public Affairs, University of Minnesota, USA https://orcid.org/0009-0008-6553-6267
MD Mehedi Hasan Medical Officer, Sylhet Medical College, Bangladesh https://orcid.org/0009-0002-5438-070X
Zahidul Mostafa Assistant Professor, Cox's Bazar Medical College, Bangladesh https://orcid.org/0000-0002-8318-0929
Rajib Kumar Malakar MS, Phase A Resident, Bangabandhu Sheikh Mujib Medical University, Bangladesh
Maherun Nesa Registrar, MS, MBBS, National Institute of Burn & Plastic Surgery, Bangladesh

Keywords: Obesity, Type 2 Diabetes, Cancer, Insulin Resistance, Inflammation, Prevention

Abstract

Obesity is becoming a global health problem, and its effects extend beyond weight gain. The condition has also been linked directly to an increased risk of type 2 diabetes and several cancers. Storage of body fat causes insulin resistance, which is one of the primary reasons for the development of type 2 diabetes. Further, obesity also generates chronic inflammation and disruption of metabolic pathways, both of which are involved in the pathogenesis of most cancers, such as breast cancer, colorectal cancer, and pancreatic cancer. It is essential to understand how obesity is connected with diabetes and cancer so that prevention can be best utilized. This paper describes how obesity heightens the risk of these diseases and highlights the significance of weight control as a preventive measure.

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